PROGNOSTIC VALUE OF N-MYC GENE AMPLIFICATION IN PATIENTS WITH NEUROBLASTOMA

This work presents the results of studying prognostic value N-MYC gene amplification in patients with neuroblastoma treated according to European protocol NB-2004. A retrospective analysis 140 who were diagnosed from 2013-2019 was carried out at SCP and PS. When collecting data neuroblastoma, found 26 patients, which 19 died (73%), 7 are alive (survival rate -27%). Amplification NMYC occurred same frequency boys girls, 50% each group. In children under one year old, there 6 (23.1%), 1-2 years old 12 (46.2%), 2-5 5 (19.2%), over 3 (11.5%). 13 (50%) children, primary tumor localized adrenal glands, 11 (42%) - retroperitoneal space 2 (7.7%) mediastinum. 21 (80.8%) gene, disease stage IV, cases IVs, 1 (3.8%) case I, II, III disease. Thus, more often detected IV had an unfavorable outcome.The fact negative impact is confirmed our study. The therapeutic ineffective presence 27%). Keywords: Neuroblastoma, amplification, prognosis, children.